Title : Effects of flurbiprofen and its enantiomers on the spinal c-Fos protein expression induced by noxious heat stimuli in the anaesthetized rat.

Pub. Date : 2000 Oct 6

PMID : 11011034






2 Functional Relationships(s)
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1 Effects of flurbiprofen and its enantiomers on the spinal c-Fos protein expression induced by noxious heat stimuli in the anaesthetized rat. Flurbiprofen Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 The same doses of R(-)-flurbiprofen produced dose-related effects (r=0.58, P<0.05) with weak, but significant, effects for doses of 3 and 9 mg/kg (18+/-6% and 26+/-5% reduction of the number of noxious heat-evoked c-Fos-IR nuclei in laminae I-II, P<0.05 and P<0.01, respectively). Flurbiprofen Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus