Title : Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2).

Pub. Date : 2000 Dec 22

PMID : 11006278






1 Functional Relationships(s)
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1 However, inter-helical distances calculated and determined by EPR for PGHS-2 complexed with arachidonic acid, flurbiprofen, and SC-58125 were in close agreement with those obtained from the cognate crystal structures. Flurbiprofen prostaglandin-endoperoxide synthase 2 Homo sapiens