Title : The novel anti-tumour agent oxamflatin differentially regulates urokinase and plasminogen activator inhibitor type 2 expression and inhibits urokinase-mediated proteolytic activity.

Pub. Date : 2000 Jun 21

PMID : 11004477






1 Functional Relationships(s)
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1 We have identified the hydroxamic acid derivative oxamflatin, previously noted to revert the malignant phenotype in K-ras-transformed NIH-3T3 cells, as capable of upregulating PAI-2 and simultaneously suppressing u-PA expression in two different cell systems. Hydroxamic Acids plasminogen activator, urokinase Mus musculus