Title : p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes.

Pub. Date : 2000 Oct 1

PMID : 10998350






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Methoxy-polyethylene glycol-maleimide MW 2000 (MAL-PEG) was used to covalently tag p53 protein that was oxidized at cysteine residues in cultured cells. Cysteine tumor protein p53 Homo sapiens
2 The oxidized p53 had an average of one cysteine residue oxidized per p53 protein molecule. Cysteine tumor protein p53 Homo sapiens
3 The oxidized p53 had an average of one cysteine residue oxidized per p53 protein molecule. Cysteine tumor protein p53 Homo sapiens
4 The data indicate that an average of one cysteine residue per p53 protein molecule is highly sensitive to oxidation and that p53 can be efficiently oxidized by PDTC in cultured cells. Cysteine tumor protein p53 Homo sapiens