Title : The reactivity of myeloperoxidase compound I formed with hypochlorous acid.

Pub. Date : 2000

PMID : 10994870






11 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The reactivity of myeloperoxidase compound I formed with hypochlorous acid. Hypochlorous Acid myeloperoxidase Homo sapiens
2 The reaction of human myeloperoxidase (MPO) with hypochlorous acid (HOCl) was investigated by conventional stopped-flow spectroscopy at pH 5, 7, and 9. Hypochlorous Acid myeloperoxidase Homo sapiens
3 The reaction of human myeloperoxidase (MPO) with hypochlorous acid (HOCl) was investigated by conventional stopped-flow spectroscopy at pH 5, 7, and 9. Hypochlorous Acid myeloperoxidase Homo sapiens
4 The reaction of human myeloperoxidase (MPO) with hypochlorous acid (HOCl) was investigated by conventional stopped-flow spectroscopy at pH 5, 7, and 9. Hypochlorous Acid myeloperoxidase Homo sapiens
5 The reaction of human myeloperoxidase (MPO) with hypochlorous acid (HOCl) was investigated by conventional stopped-flow spectroscopy at pH 5, 7, and 9. Hypochlorous Acid myeloperoxidase Homo sapiens
6 In the reaction of MPO with HOCl, compound I is formed. Hypochlorous Acid myeloperoxidase Homo sapiens
7 The results show conclusively that the redox intermediates formed upon addition of either hydrogen peroxide or hypochlorous acid to native MPO exhibit the same spectral features and reactivities and thus are identical. Hypochlorous Acid myeloperoxidase Homo sapiens
8 In stopped-flow investigations, the MPO/HOCl system has some advantage since: (i) in contrast to H2O2, HOCl cannot function as a one-electron donor of compound I; and (ii) MPO can easily be prevented from cycling by addition of methionine as HOCl scavenger. Hypochlorous Acid myeloperoxidase Homo sapiens
9 In stopped-flow investigations, the MPO/HOCl system has some advantage since: (i) in contrast to H2O2, HOCl cannot function as a one-electron donor of compound I; and (ii) MPO can easily be prevented from cycling by addition of methionine as HOCl scavenger. Hypochlorous Acid myeloperoxidase Homo sapiens
10 In stopped-flow investigations, the MPO/HOCl system has some advantage since: (i) in contrast to H2O2, HOCl cannot function as a one-electron donor of compound I; and (ii) MPO can easily be prevented from cycling by addition of methionine as HOCl scavenger. Hypochlorous Acid myeloperoxidase Homo sapiens
11 In stopped-flow investigations, the MPO/HOCl system has some advantage since: (i) in contrast to H2O2, HOCl cannot function as a one-electron donor of compound I; and (ii) MPO can easily be prevented from cycling by addition of methionine as HOCl scavenger. Hypochlorous Acid myeloperoxidase Homo sapiens