Pub. Date : 2000 Aug
PMID : 10977131
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The selectivity of S(+) flurbiprofen for inhibition of COX-1 was expressed as the ratio of IC50 for COX-2/COX-1. | Flurbiprofen | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | S(+) flurbiprofen inhibited PGE2 production of untreated tissue homogenates at an IC50 of 8 x 10(-10) M whereas, in the stimulated tissue, IC50 was found to be 3 x 10(-6) M. The selectivity of S(+) flurbiprofen for inhibition of constitutively present COX-1, relative to the inhibition of induced COX-2, was 3,600. | Flurbiprofen | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |