Title : Suppression of sorbitol dependence in a strain bearing a mutation in the SRB1/PSA1/VIG9 gene encoding GDP-mannose pyrophosphorylase by PDE2 overexpression suggests a role for the Ras/cAMP signal-transduction pathway in the control of yeast cell-wall biogenesis.

Pub. Date : 2000 Sep

PMID : 10974101






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1 Suppression of sorbitol dependence in a strain bearing a mutation in the SRB1/PSA1/VIG9 gene encoding GDP-mannose pyrophosphorylase by PDE2 overexpression suggests a role for the Ras/cAMP signal-transduction pathway in the control of yeast cell-wall biogenesis. Sorbitol 3',5'-cyclic-nucleotide phosphodiesterase PDE2 Saccharomyces cerevisiae S288C
2 A previously reported complementing gene, which this study has now identified as PDE2, is a multi-copy suppressor of sorbitol dependence and is not, as was previously suggested, the SRB1 gene. Sorbitol 3',5'-cyclic-nucleotide phosphodiesterase PDE2 Saccharomyces cerevisiae S288C