Title : Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Pub. Date : 2000 Sep 12

PMID : 10973490






2 Functional Relationships(s)
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1 Here we show that in vitro, ATM phosphorylates the Ser-Gln/Thr-Gln (SQ/TQ) cluster domain (SCD) on Chk2, which contains seven SQ/TQ motifs, and Thr68 is the major in vitro phosphorylation site by ATM. Glutamine checkpoint kinase 2 Homo sapiens
2 Here we show that in vitro, ATM phosphorylates the Ser-Gln/Thr-Gln (SQ/TQ) cluster domain (SCD) on Chk2, which contains seven SQ/TQ motifs, and Thr68 is the major in vitro phosphorylation site by ATM. Glutamine checkpoint kinase 2 Homo sapiens