Pub. Date : 2000 Sep
PMID : 10973244
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. | polyglutamine | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | We found that expanded polyQ stretches preferentially bind to TAFII130, a coactivator involved in cAMP-responsive element binding protein (CREB)-dependent transcriptional activation, and strongly suppress CREB-dependent transcriptional activation. | polyglutamine | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | We found that expanded polyQ stretches preferentially bind to TAFII130, a coactivator involved in cAMP-responsive element binding protein (CREB)-dependent transcriptional activation, and strongly suppress CREB-dependent transcriptional activation. | polyglutamine | cAMP responsive element binding protein 1 | Homo sapiens |
| 4 | We found that expanded polyQ stretches preferentially bind to TAFII130, a coactivator involved in cAMP-responsive element binding protein (CREB)-dependent transcriptional activation, and strongly suppress CREB-dependent transcriptional activation. | polyglutamine | cAMP responsive element binding protein 1 | Homo sapiens |
| 5 | The suppression of CREB-dependent transcription and the cell death induced by polyQ stretches were restored by the co-expression of TAFII130. | polyglutamine | cAMP responsive element binding protein 1 | Homo sapiens |