Pub. Date : 2000 Sep
PMID : 10972672
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Consistently, transfection with dominant-negative mutants of ERK1 and ERK2 or a dominant-negative mutant of JNK inhibited H2O2-induced apoptosis. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |