Title : Enhanced expression of the leukotriene C(4) synthase due to overactive transcription of an allelic variant associated with aspirin-intolerant asthma.

Pub. Date : 2000 Sep

PMID : 10970818






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The gene coding for leukotriene (LT) C(4) synthase (LTC(4)S), the enzyme controlling cys-LT biosynthesis, exists as two common alleles distinguished by an A to C transversion at a site 444 nucleotides upstream of the translation start. Cysteine leukotriene C4 synthase Homo sapiens
2 The gene coding for leukotriene (LT) C(4) synthase (LTC(4)S), the enzyme controlling cys-LT biosynthesis, exists as two common alleles distinguished by an A to C transversion at a site 444 nucleotides upstream of the translation start. Cysteine leukotriene C4 synthase Homo sapiens
3 Genetic predisposition to cys-LT pathway upregulation, a hallmark of AIA, can be related to overactive expression of the LTC(4)S (-444)C allele. Cysteine leukotriene C4 synthase Homo sapiens