Pub. Date : 2000 Jul
PMID : 10962261
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Positron emission tomography study of pindolol occupancy of 5-HT(1A) receptors in humans: preliminary analyses. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 2 | Preclinical studies in rodents suggest that augmentation of serotonin reuptake inhibitors (SSRIs) therapy by the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor agent pindolol might reduce the delay between initiation of treatment and antidepressant response. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 3 | This hypothesis is based on the ability of pindolol to potentiate the increase in serotonin (5-HT) transmission induced by SSRIs, an effect achieved by blockade of the 5-HT(1A) autoreceptors in the dorsal raphe nuclei (DRN). | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 4 | Here, we evaluated the occupancy of 5-HT(1A) receptors following treatment with controlled release pindolol in nine healthy volunteers with positron-emission tomography (PET). | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 5 | On the other hand, at each dose tested, pindolol occupancy of 5-HT(1A) receptors was higher in the DRN compared to cortical regions, demonstrating a significant in vivo selectivity for DRN 5-HT(1A) autoreceptors relative to cortico-limbic postsynaptic receptors. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 6 | On the other hand, at each dose tested, pindolol occupancy of 5-HT(1A) receptors was higher in the DRN compared to cortical regions, demonstrating a significant in vivo selectivity for DRN 5-HT(1A) autoreceptors relative to cortico-limbic postsynaptic receptors. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |