Title : Regulation of cloned ATP-sensitive K channels by phosphorylation, MgADP, and phosphatidylinositol bisphosphate (PIP(2)): a study of channel rundown and reactivation.

Pub. Date : 2000 Sep

PMID : 10962016






3 Functional Relationships(s)
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1 With Kir6.2-GFP+SUR1, slow rundown also caused loss of MgADP stimulation and sulfonylurea inhibition, suggesting functional uncoupling of SUR1 from Kir6.2-GFP. Adenosine Diphosphate potassium inwardly rectifying channel subfamily J member 11 Homo sapiens
2 With Kir6.2-GFP+SUR1, slow rundown also caused loss of MgADP stimulation and sulfonylurea inhibition, suggesting functional uncoupling of SUR1 from Kir6.2-GFP. Adenosine Diphosphate potassium inwardly rectifying channel subfamily J member 11 Homo sapiens
3 In summary, short-term regulation of Kir6.2+SUR1 channels involves MgADP, while long-term regulation requires PIP(2) and phosphorylation. Adenosine Diphosphate potassium inwardly rectifying channel subfamily J member 11 Homo sapiens