Title : Regulation of cloned ATP-sensitive K channels by phosphorylation, MgADP, and phosphatidylinositol bisphosphate (PIP(2)): a study of channel rundown and reactivation.

Pub. Date : 2000 Sep

PMID : 10962016






3 Functional Relationships(s)
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1 Upon excision of inside-out patches into a Ca(2+)- and MgATP-free solution, the activity of Kir6.2-GFP+SUR1 channels spontaneously ran down, first quickly within a minute, and then more slowly over tens of minutes. Adenosine Triphosphate ATP binding cassette subfamily C member 8 Homo sapiens
2 2</protein-id>-GFP+SUR1 fast phase of rundown was of variable amplitude and led to increased ATP sensitivity. Adenosine Triphosphate ATP binding cassette subfamily C member 8 Homo sapiens
3 With both Kir6.2-GFP and Kir6.2-GFP+SUR1, the slow phase of rundown led to further increase in ATP sensitivity. Adenosine Triphosphate ATP binding cassette subfamily C member 8 Homo sapiens