Title : Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.

Pub. Date : 2000 Oct 1

PMID : 10960769






2 Functional Relationships(s)
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1 Hypomethylated and over-expression of c-jun and c-myc genes were found in DCA- and TCA-promoted liver tumors. Dichloroacetic Acid jun proto-oncogene Mus musculus
2 Thus, DCA- and TCA-promoted carcinogenesis appears to include decreased methylation and increased expression of c-jun and c-myc genes in the presence of increased DNA MTase activity. Dichloroacetic Acid jun proto-oncogene Mus musculus