Title : Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes.

Pub. Date : 2000 Sep

PMID : 10960082






1 Functional Relationships(s)
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1 The stimulatory action of IL-1beta on PGE(2) production was totally abolished by NS-398, a specific inhibitor of cyclo-oxygenase-2 activity, as well as by the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone. Dinoprostone prostaglandin-endoperoxide synthase 2 Mus musculus