Pub. Date : 2000 Sep
PMID : 10960075
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. | SB 203580 | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Overexpression of kinase-deficient mutants belonging to the ERK1/2, JNK, and p38 pathways showed that only dominant-negative Raf-1 abrogated SB203580-enhanced NF-kappaB activity. | SB 203580 | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | This would implicate the involvement of the ERK1/2 pathway in the enhancing effects of SB203580 on NF-kappaB-mediated gene transcription. | SB 203580 | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-kappaB transcriptional activity. | SB 203580 | mitogen-activated protein kinase 3 | Homo sapiens |