Title : Prevention by dexrazoxane of down-regulation of ryanodine receptor gene expression in anthracycline cardiomyopathy in the rat.

Pub. Date : 2000 Sep

PMID : 10960060






1 Functional Relationships(s)
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1 Dexrazoxane pre-treatment (50 mg kg(-1); 1 h prior to each daunorubicin injection) prevented the decrease in RyR2/GAPDH mRNA ratio and histopathologic lesions in daunorubicin-treated rats. Dexrazoxane glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus