Title : Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.

Pub. Date : 2000 Jul-Aug

PMID : 10953335






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cyclooxygenase (COX), also referred to as prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids. Eicosanoids mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Furthermore, indomethacin and NS398 were equipotent for growth inhibition and induction of apoptosis, indicating that eicosanoid synthesis via COX-2 is involved in pancreatic cancer cell proliferation and survival. Eicosanoids mitochondrially encoded cytochrome c oxidase II Homo sapiens