Pub. Date : 2000 Sep
PMID : 10945841
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | with four daily doses of PB demonstrated markedly induced levels of CYP2B1, CYP2B2, and CYP3A1 mRNA in the striatum and cerebellum. | Phenobarbital | cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 | Rattus norvegicus |
| 2 | Substantial activation of cerebral CYP2B1, CYP2B2, and CYP3A1 mRNA levels also resulted when animals were treated with the neuroactive drugs diphenylhydantoin and amitryptiline, and with the potential PB-like xenobiotic inducers trans-stilbene oxide and diallyl sulfide, whereas dichlorodiphenyltrichloroethane was less efficacious. | Phenobarbital | cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 | Rattus norvegicus |