Title : SHIP inhibits Akt activation in B cells through regulation of Akt membrane localization.

Pub. Date : 2000 Aug 15

PMID : 10942391






1 Functional Relationships(s)
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1 Because SHIP dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) and activation of Akt requires PIP3, the destruction of this phospholipid has been proposed as the mechanism for Akt inhibition. Phospholipids inositol polyphosphate-5-phosphatase D Homo sapiens