Title : Hydrogen peroxide inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun N-terminal kinase and p38 associated with protein kinase C.

Pub. Date : 2000 Jul 20

PMID : 10936514






2 Functional Relationships(s)
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Protein Name
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1 H(2)O(2) produced a marked and dose-related inhibition of both lipopolysaccharide (LPS)-induced B-cell proliferation and concanavalin A (Con A)-induced T-cell proliferation. Hydrogen Peroxide toll-like receptor 4 Mus musculus
2 In addition, H(2)O(2) pretreatment blocked the phosphorylation of two stress-activated mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinase (JNK) and p38 by LPS in a concentration-dependent fashion. Hydrogen Peroxide toll-like receptor 4 Mus musculus