Pub. Date : 2000 Aug 15
PMID : 10931533
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The main goal of this study was to investigate effects of typical (haloperidol) and atypical (risperidone) antipsychotic drugs on brain regional neuropeptide Y (NPY)-like immunoreactivity (-LI) tissue concentrations and on release of NPY-LI in freely moving rats. | Haloperidol | neuropeptide Y | Rattus norvegicus |
| 2 | The main goal of this study was to investigate effects of typical (haloperidol) and atypical (risperidone) antipsychotic drugs on brain regional neuropeptide Y (NPY)-like immunoreactivity (-LI) tissue concentrations and on release of NPY-LI in freely moving rats. | Haloperidol | neuropeptide Y | Rattus norvegicus |
| 3 | Haloperidol significantly increased NPY-LI in hypothalamus and the occipital cortex. | Haloperidol | neuropeptide Y | Rattus norvegicus |
| 4 | In contrast, haloperidol decreased tissue levels of NPY-LI in striatum. | Haloperidol | neuropeptide Y | Rattus norvegicus |
| 5 | Moreover, haloperidol and risperidone also significantly decreased extracellular NPY-LI concentrations in the ventral striatum. | Haloperidol | neuropeptide Y | Rattus norvegicus |
| 6 | The results show that d-amphetamine as well as haloperidol and risperidone selectively and specifically affect NPY-LI concentrations in brain tissue and microdialysates and that the effect of d-amphetamine is abolished by both typical and atypical antipsychotics. | Haloperidol | neuropeptide Y | Rattus norvegicus |