Pub. Date : 2000 Jul-Aug
PMID : 10930042
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the apoptosis cascade, upregulation of Bax, downregulation of Bcl-2, and increased CPP32 protease (caspase-3) activity were seen 12 hours after MNU dosing. | Methylnitrosourea | BCL2 associated X, apoptosis regulator | Rattus norvegicus |
| 2 | Therefore, the pathogenesis of MNU-induced cataract was associated with DNA adduct formation in the lens epithelial cell nuclei leading to apoptosis by upregulation of Bax protein, downmodulation of Bcl-2 protein, and activation of caspase-3. | Methylnitrosourea | BCL2 associated X, apoptosis regulator | Rattus norvegicus |