Pub. Date : 2000 Aug
PMID : 10928971
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells. | Tacrolimus | tumor necrosis factor | Homo sapiens |
| 2 | The aim of this study was to elucidate the in vitro inhibitory potency of FK506 on production of the inflammatory cytokines, tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta, with a view to assessing this immunosuppressive agent as a potential anti-rheumatic drug. | Tacrolimus | tumor necrosis factor | Homo sapiens |
| 3 | FK506 inhibited anti-CD3/CD28 induced TNF-alpha and IL-1beta production at concentrations less than 1 ng ml(-1). | Tacrolimus | tumor necrosis factor | Homo sapiens |
| 4 | Flow cytometric analysis of intracellular TNF-alpha and IL-1beta positive cells showed that FK506 potently suppresses inflammatory cytokine production from CD14+ monocytes as well as from T cells. | Tacrolimus | tumor necrosis factor | Homo sapiens |