Title : Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans.

Pub. Date : 2000 Aug

PMID : 10926654






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1 Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans. Deferoxamine erythropoietin Homo sapiens
2 The first aim of this study was to examine whether an infusion of desferrioxamine (DFO) increased serum Epo in humans. Deferoxamine erythropoietin Homo sapiens
3 The first aim of this study was to examine whether an infusion of desferrioxamine (DFO) increased serum Epo in humans. Deferoxamine erythropoietin Homo sapiens
4 The results show that 1) compared with control, Epo increased in most subjects at 8 h [52.8 +/- 57.7 vs. 6.9 +/- 2.5 (SD) mIU/ml, for DFO = 4 g/70 kg body wt, P < 0.05] and 12 h (63.7 +/- 76.3 vs. 7.3 +/- 2.5 mIU/ml, P < 0.001) after the start of DFO administration and 2) DFO had no significant effect on AHVR. Deferoxamine erythropoietin Homo sapiens
5 We conclude that, whereas infusions of DFO mimic hypoxia by increasing Epo, they do not mimic prolonged hypoxia by augmenting AHVR. Deferoxamine erythropoietin Homo sapiens