Pub. Date : 2000 Aug
PMID : 10924071
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production. | Tetradecanoylphorbol Acetate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | PMA increased COX-2 protein levels 2. | Tetradecanoylphorbol Acetate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Inhibition of either p38 kinase or protein kinase C (PKC) prevented PMA-stimulated COX-2. | Tetradecanoylphorbol Acetate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | These findings indicate that: 1) PMA, acting through PKC and p38 kinase, enhances COX-2 expression, but chronic treatment with PMA partially inhibits IL-1beta stimulation of COX-2; and 2) exogenous PGF(2alpha) is involved in neonatal ventricular myocyte growth but endogenous COX-2 products are not. | Tetradecanoylphorbol Acetate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |