Pub. Date : 2000 Oct 13
PMID : 10918061
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By using phosphoamino acid analysis we found that Ser residues of c-Mpl were constitutively phosphorylated in receptor-bearing cells, levels that were increased following exposure of cells to TPO. | Serine | thrombopoietin | Homo sapiens |
| 2 | To identify which residues were modified, and to determine the functional consequences of their phosphorylation, we generated a series of Ser to Ala mutations of a truncated c-Mpl receptor (T69) capable of supporting TPO-induced cell growth. | Serine | thrombopoietin | Homo sapiens |
| 3 | Of the eight Ser within T69 we found that at least four are phosphorylated in TPO-stimulated cells. | Serine | thrombopoietin | Homo sapiens |