Title : Activation of protein kinase C induces nuclear translocation of RFX1 and down-regulates c-myc via an intron 1 X box in undifferentiated leukemia HL-60 cells.

Pub. Date : 2000 Oct 13

PMID : 10918054






3 Functional Relationships(s)
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1 Treatment of human promyelocytic leukemia cells (HL-60) with phorbol 12-myristate 13-acetate (PMA) is known to decrease c-myc mRNA by blocking transcription elongation at sites near the first exon/intron border. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Treatment of human promyelocytic leukemia cells (HL-60) with phorbol 12-myristate 13-acetate (PMA) is known to decrease c-myc mRNA by blocking transcription elongation at sites near the first exon/intron border. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 Treatment with PMA or bryostatin 1 increased nuclear protein binding to MIE1, a c-myc intron 1 element that defines an RFX1-binding X box. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens