Pub. Date : 2000 Jul 1
PMID : 10910061
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we have determined the expression patterns of dUTPase in normal and neoplastic tissues and examined the association between dUTPase expression and response to 5-fluorouracil (5-FU)-based chemotherapy and overall survival in colorectal cancer. | Fluorouracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 2 | In this study, we have determined the expression patterns of dUTPase in normal and neoplastic tissues and examined the association between dUTPase expression and response to 5-fluorouracil (5-FU)-based chemotherapy and overall survival in colorectal cancer. | Fluorouracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 3 | To examine the association between dUTPase expression and response to 5-FU-based chemotherapy and overall survival, we initiated a retrospective study including tumor specimens from 20 patients who had received protracted infusion of 5-FU and leucovorin for treatment of metastatic colon cancer. | Fluorouracil | Deoxyuridine triphosphatase | Drosophila melanogaster |
| 4 | This study demonstrates that low intratumoral levels of nuclear dUTPase protein expression is associated with response to 5-FU-based chemotherapy, greater time to progression, and greater overall survival in colorectal cancer. | Fluorouracil | Deoxyuridine triphosphatase | Drosophila melanogaster |