Title : IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.

Pub. Date : 2000 Aug 1

PMID : 10903743






2 Functional Relationships(s)
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1 Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3. Nickel CD4 molecule Homo sapiens
2 Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously than supernatant from keratinocytes activated with IFN-gamma alone. Nickel CD4 molecule Homo sapiens