Title : Proteolytic modulation of thrombopoietin activity: comparison of thrombin, plasmin, and urokinase.

Pub. Date : 2000 Jun

PMID : 10896248






1 Functional Relationships(s)
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1 In contrast, plasmin cleaves Tpo sequentially at two specific sites (Arg(205) within the glycan domain followed by Lys(52) within the cytokine domain), and is associated with a marked decrease in Tpo activity. Polysaccharides plasminogen Homo sapiens