Title : Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels.

Pub. Date : 2000 Jul

PMID : 10880954






1 Functional Relationships(s)
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1 TNF-alpha (10 ng.mL-1) and C8-ceramide (20 microM) inhibited the incorporation of [3H]thymidine into DNA and led to an accumulation of cells in the G1 phase of the cell cycle. 3h]thymidine tumor necrosis factor Homo sapiens