Title : Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase.

Pub. Date : 2000 Jul 15

PMID : 10880360






1 Functional Relationships(s)
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1 These findings indicate that, following activation of PI 3-kinases, PtdIns(3,4,5)P(3) or PtdIns(3,4)P(2) bind to DAPP1, recruiting it to the plasma membrane where it becomes phosphorylated at Tyr(139) by a Src-family tyrosine kinase. phosphoinositide-3,4-bisphosphate SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens