Pub. Date : 2000 Jul 15
PMID : 10880360
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DAPP1 exhibits a high-affinity interaction with PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), which bind to the PH domain. | phosphoinositide-3,4-bisphosphate | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 | Homo sapiens |
| 2 | Treatment of cells with phosphoinositide 3-kinase (PI 3-kinase) inhibitors or expression of a dominant-negative PI 3-kinase prevent phosphorylation of DAPP1 at Tyr(139), and a PH-domain mutant of DAPP1, which does not interact with PtdIns(3,4,5)P(3) or PtdIns(3,4)P(2), is not phosphorylated at Tyr(139) following agonist stimulation of cells. | phosphoinositide-3,4-bisphosphate | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 | Homo sapiens |
| 3 | These findings indicate that, following activation of PI 3-kinases, PtdIns(3,4,5)P(3) or PtdIns(3,4)P(2) bind to DAPP1, recruiting it to the plasma membrane where it becomes phosphorylated at Tyr(139) by a Src-family tyrosine kinase. | phosphoinositide-3,4-bisphosphate | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 | Homo sapiens |