Title : Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase.

Pub. Date : 2000 Sep 22

PMID : 10875931






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The SH2-containing inositol 5"-phosphatase (SHIP) is tyrosine-phosphorylated in response to cytokines such as interleukin (IL)-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor. Tyrosine inositol polyphosphate-5-phosphatase D Homo sapiens
2 The SH2-containing inositol 5"-phosphatase (SHIP) is tyrosine-phosphorylated in response to cytokines such as interleukin (IL)-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor. Tyrosine inositol polyphosphate-5-phosphatase D Homo sapiens
3 It has been recently shown that IL-4 induces tyrosine phosphorylation of SHIP, implicating the phosphatase in IL-4 processes. Tyrosine inositol polyphosphate-5-phosphatase D Homo sapiens
4 Tyrosine kinases, Jak1 and Jak3, involved in IL-4 signaling can associate with SHIP, yet only Jak1 can tyrosine-phosphorylate SHIP when co-expressed. Tyrosine inositol polyphosphate-5-phosphatase D Homo sapiens