Title : Detoxication of vinca alkaloids by human P450 CYP3A4-mediated metabolism: implications for the development of drug resistance.

Pub. Date : 2000 Jul

PMID : 10871337






2 Functional Relationships(s)
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1 Similarly, treatment of the human colon adenocarcinoma cell line LS174T with vinblastine selected for a cell population with higher levels of endogenous CYP3A4 as revealed by immunohistochemistry without simultaneous increase of multidrug resistance protein 1 (MDR1). Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens
2 Similarly, treatment of the human colon adenocarcinoma cell line LS174T with vinblastine selected for a cell population with higher levels of endogenous CYP3A4 as revealed by immunohistochemistry without simultaneous increase of multidrug resistance protein 1 (MDR1). Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens