Title : Detoxication of vinca alkaloids by human P450 CYP3A4-mediated metabolism: implications for the development of drug resistance.

Pub. Date : 2000 Jul

PMID : 10871337






1 Functional Relationships(s)
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1 Whereas vincristine and vinblastine at a concentration of 100 nM killed more than 90% of the parental cells, more than 50 and 35%, respectively, of cells that coexpressed CYP3A4 and cytochrome P450 (P450) reductase survived these treatments. Vinblastine cytochrome P450 family 4 subfamily F member 3 Homo sapiens