Pub. Date : 2000 Jul
PMID : 10871310
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential inhibition of the prejunctional actions of angiotensin II in rat atria by valsartan, irbesartan, eprosartan, and losartan. | Valsartan | angiotensinogen | Rattus norvegicus |
| 2 | Pretreatment of tissues with valsartan, irbesartan, eprosartan, or losartan (10(-8) to 10(-6) M) produced concentration-dependent inhibitions of the stimulation-induced efflux of radioactivity observed in the presence of angiotensin II (10(-7) M). | Valsartan | angiotensinogen | Rattus norvegicus |
| 3 | Thus, valsartan is a potent inhibitor of the prejunctional facilitatory effect of angiotensin II on the release of norepinephrine from peripheral sympathetic nerves. | Valsartan | angiotensinogen | Rattus norvegicus |
| 4 | This implies that the therapeutic domain of valsartan may be extended to include pathophysiological conditions such as congestive heart failure wherein prejunctional angiotensin II receptors apparently play a significant role. | Valsartan | angiotensinogen | Rattus norvegicus |