Pub. Date : 2000
PMID : 10865942
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction of fibrinogen with saphenous vein endothelial cells stimulates tyrosine phosphorylation of cortactin. | Tyrosine | fibrinogen beta chain | Homo sapiens |
| 2 | We have investigated the effect of fibrinogen on the tyrosine phosphorylation of cortactin, a cytoskeletal protein in human saphenous vein endothelial cells (HSVECs). | Tyrosine | fibrinogen beta chain | Homo sapiens |
| 3 | Incubation of HSVECs with fibrinogen (0-4 microM) caused a concentration-dependent increase in the tyrosine phosphorylation of cortactin. | Tyrosine | fibrinogen beta chain | Homo sapiens |
| 4 | Fibrinogen (4 microM) and fibrinogen fragment D (4 microM) caused 250% and >450% increase in tyrosine phosphorylation of cortactin respectively, but fibrinogen fragment E (50 kDa form) was ineffective. | Tyrosine | fibrinogen beta chain | Homo sapiens |
| 5 | Fibrinogen (4 microM) and fibrinogen fragment D (4 microM) caused 250% and >450% increase in tyrosine phosphorylation of cortactin respectively, but fibrinogen fragment E (50 kDa form) was ineffective. | Tyrosine | fibrinogen beta chain | Homo sapiens |
| 6 | At physiological concentrations fibrinogen binds to receptors (probably including ICAM-1) on HSVECs, to increase tyrosine phosphorylation of cortactin. | Tyrosine | fibrinogen beta chain | Homo sapiens |