Title : Anaesthetic agents inhibit gastrin-stimulated but not basal histamine release from rat stomach ECL cells.

Pub. Date : 2000 Jun

PMID : 10864877






7 Functional Relationships(s)
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1 By mobilizing histamine in response to gastrin, the ECL cells in the oxyntic mucosa play a key role in the control of the parietal cells and hence of gastric acid secretion. Histamine gastrin Rattus norvegicus
2 The present study examines if the effect of anaesthesia on basal and gastrin-stimulated acid secretion is associated with suppressed ECL-cell histamine secretion. Histamine gastrin Rattus norvegicus
3 The reduction in gastrin-induced acid response (70 - 95%) was strongly correlated to the reduction in gastrin-induced histamine mobilization. Histamine gastrin Rattus norvegicus
4 The reduction in gastrin-induced acid response (70 - 95%) was strongly correlated to the reduction in gastrin-induced histamine mobilization. Histamine gastrin Rattus norvegicus
5 The correlation is in line with the view that the reduced acid response to gastrin reflects impaired histamine mobilization. Histamine gastrin Rattus norvegicus
6 Gastrin-evoked histamine mobilization from the isolated ECL cells was determined in the absence or presence of anaesthetic agents in the medium. Histamine gastrin Rattus norvegicus
7 With the exception of urethane, they inhibited gastrin-evoked histamine secretion dose-dependently, indicating a direct effect on the ECL cells. Histamine gastrin Rattus norvegicus