Pub. Date : 2000 Jun 15
PMID : 10862804
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 5-HT(1A) agonist potential of pindolol: electrophysiologic studies in the dorsal raphe nucleus and hippocampus. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 2 | BACKGROUND: The ability of pindolol to block 5-HT(1A) autoreceptors on serotonin-containing neurons in the raphe nuclei is thought to underlie the clinical reports of enhanced efficacy and rate of improvement in depressed patients treated with pindolol/selective serotonin reuptake inhibitor (SSRI) combinations. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 3 | BACKGROUND: The ability of pindolol to block 5-HT(1A) autoreceptors on serotonin-containing neurons in the raphe nuclei is thought to underlie the clinical reports of enhanced efficacy and rate of improvement in depressed patients treated with pindolol/selective serotonin reuptake inhibitor (SSRI) combinations. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |
| 4 | The 5-HT(1A)-independent inhibition of hippocampal CA3 cell firing by pindolol suggests that this compound invokes multiple pharmacologic actions, all of which need to be assimilated into any proposed mechanism of action. | Pindolol | 5-hydroxytryptamine receptor 1A | Homo sapiens |