Pub. Date : 2000 Jun
PMID : 10862525
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol. | 4-hydroxyestradiol | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | Since 4-hydroxyestradiol has been implicated in hormonal carcinogenesis and CYP1B1 is expressed in target tissues, the data presented demonstrate that polymorphisms in CYP1B1 have the potential to affect disease susceptibility. | 4-hydroxyestradiol | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |