Title : Metabolism of ticlopidine by activated neutrophils: implications for ticlopidine-induced agranulocytosis.

Pub. Date : 2000 Jul

PMID : 10859143






2 Functional Relationships(s)
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1 The oxidation products of ticlopidine by the combination of myeloperoxidase and hydrogen peroxide were the same as those by HOCl: dehydrogenated ticlopidine and 2-chloroticlopidine. Ticlopidine myeloperoxidase Homo sapiens
2 A neutrophil-derived reactive metabolite of ticlopidine was trapped with GSH and the same ticlopidine-GSH conjugate was found in both the myeloperoxidase and HOCl systems. Ticlopidine myeloperoxidase Homo sapiens