Pub. Date : 2000 Jun 9
PMID : 10856442
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of antipsychotic drugs on neurotoxicity, expression of fos-like protein and c-fos mRNA in the retrosplenial cortex after administration of dizocilpine. | Dizocilpine Maleate | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | In this study, we examined the effect of clozapine, olanzapine, risperidone and haloperidol on the neuropathology (i.e. neuronal vacuolization) and the expression of Fos-like protein and c-fos mRNA in the retrosplenial cortex of female Sprague-Dawley rats induced by the NMDA receptor antagonist dizocilpine. | Dizocilpine Maleate | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | Furthermore, pretreatment (15 min) with clozapine or olanzapine, but not risperidone or haloperidol, significantly attenuated the expression of Fos-like protein in the retrosplenial cortex induced by dizocilpine (0.5 mg/kg, s.c.) in a dose-dependent manner. | Dizocilpine Maleate | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | The marked expression of c-fos mRNA in the rat retrosplenial cortex induced by the administration of dizocilpine (0.5 mg/kg, s.c.) was significantly attenuated by pretreatment (15 min) with clozapine (10 mg/kg) or olanzapine (10 mg/kg), but not risperidone (10 mg/kg) or haloperidol (10 mg/kg). | Dizocilpine Maleate | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | The present results suggest that pharmacologically relevant doses of clozapine or olanzapine, but not risperidone or haloperidol, block the neuropathological changes and the expression of Fos-like protein and c-fos mRNA in the rat retrosplenial cortex elicited by the administration of dizocilpine. | Dizocilpine Maleate | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |