Title : Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1).

Pub. Date : 2000 Jun 15

PMID : 10856126






2 Functional Relationships(s)
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1 Whole-cell voltage-clamp techniques were used to investigate the capsaicin-, voltage- and time-dependent properties of the rat vanilloid receptor (rVR1) stably expressed in human embryonic kidney (HEK) 293 cells. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 At a holding potential of -70 mV, application of capsaicin (0.03-30 microM) to HEK 293 cells expressing the rVR1 receptor led to the appearance of inward currents (EC50, 497 nM; Hill coefficient, nH, 2.85) which were reversibly antagonized by 10 microM capsazepine. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus