Title : Articular chondrocytes from aging rats respond poorly to insulin-like growth factor-1: an altered signaling pathway.

Pub. Date : 2000 May 18

PMID : 10854627






1 Functional Relationships(s)
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1 This study investigates the effect of insulin-like growth factor-1 (IGF-1) and phorbol 12-myrystate 13-acetate (PMA) on 3H-thymidine, 35SO(4) and 3H -glycine incorporations, adenosine 3":5"-cyclic monophosphate (cAMP) production and protein kinase C (PKC) activation in cultured rat articular chondrocyte monolayers (RACM) derived from animals of different ages. 3h-thymidine insulin-like growth factor 1 Rattus norvegicus