Title : Methotrexate as a preferential cyclooxygenase 2 inhibitor in whole blood of patients with rheumatoid arthritis.

Pub. Date : 2000 May

PMID : 10852985






1 Functional Relationships(s)
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1 Assays performed with blood from RA/MTX patients showed preferential inhibition of COX-2 activity (PGE(2) = 10.11 +/- 2.42 ng/ml) when compared with blood of normal donors (PGE(2) = 37.7 +/- 4.36 ng/ml; P = 0.001). Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens