Title : Differential activity of the cytochrome P450 17alpha-hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells.

Pub. Date : 2000 Jun

PMID : 10852468






2 Functional Relationships(s)
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1 Cotransfection of a steroidogenic factor-1 expression plasmid was found to be required for detection of basal and forskolin-stimulated CYP17 promoter activity but not for StAR promoter activity. Colforsin cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Basal and forskolin-stimulated CYP17 promoter activity was 4-fold greater in PCOS cells than in theca cells isolated from normal ovaries. Colforsin cytochrome P450 family 17 subfamily A member 1 Homo sapiens