Title : A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

Pub. Date : 2000 Jun

PMID : 10847581






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Adenovirus-mediated expression of a membrane-targeted form of the p110 subunit of phosphatidylinositol (PI) 3-kinase (p110CAAX) induced a mobility shift and degradation of IRS-1, both of which were inhibited by rapamycin. Phosphatidylinositols insulin receptor substrate 1 Homo sapiens